DNA hasarı yapan kanser tedavilerinin yararını arttırmada hiperterminin etkinliği

DNA hasarı yapan kanser tedavilerinin yararını arttırmada hiperterminin etkinliği

Kategori   Hipertermi   | 4/24/2017

 

Hipertermi bölümüne aşağıdaki başlık ile olduğu gibi eklenmesi. Bold karakterlerin aynı kalması. 
DNA hasarı yapan kanser tedavilerinin yararını arttırmada hiperterminin etkinliği
 
İngiltere, Amerika Birleşik Devletleri ve Yunanistan’ dan bilim insanlarının ortaklaşa yaptığı araştırmada hiperterminin kemoterapi ve / veya radyoterapinin yanında tamamlayıcı tedavi olarak uygulandığında tedavinin kanser hücrelerini öldürücü etkisini nasıl arttırdığı anlatılmaktadır. Kanser hücrelerinin DNA’ sında tıbbi tedavi ile yaratılan öldürücü hasar kanser hücrelerinin koruyucu mekanizmaları tarafından tamir edilmektedir. Hipertermi kanser hücrelerindeki hasarın tamirini engellemede fayda sağlamaktadır. Kendisini tamir etme yeteneğini hipertermi uygulaması ile kaybeden kanser hücreleri tıbbi tedavi ile daha kolay öldürülmektedir. Ek bilgi için iletişim telefonlarından yardım alabilirsiniz. 
 
Semin Cancer Biol. 2016 Jun;37-38:96-105. doi: 10.1016/j.semcancer.2016.03.004. Epub 2016 Mar 26.
Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies.
Mantso T1, Goussetis G2, Franco R3, Botaitis S4, Pappa A5, Panayiotidis M6.
Author information
1School of Life Sciences, Heriot Watt University, Edinburgh, Scotland, UK.
2School of Engineering & Physical Sciences, Heriot Watt University, Edinburgh, Scotland, UK.
3School of Veterinary Medicine & Biomedical Sciences, University of Nebraska-Lincoln, USA.
4Second Department of Surgery, Democritus University of Thrace, Alexandroupolis, Greece.
5Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, Greece.
6School of Life Sciences, Heriot Watt University, Edinburgh, Scotland, UK. Electronic address: M.Panagiotidis@hw.ac.uk.
Abstract
Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (over the last few decades) since various studies have shed light into understanding hyperthermia's underlying molecular mechanism(s) of action. In general, hyperthermia is applied as complementary (adjuvant) means in therapeutic protocols combining chemotherapy and/or irradiation both of which can induce irreversible cellular DNA damage. Furthermore, according to a number of in vitro, in vivo and clinical studies, hyperthermia has been shown to enhance the beneficial effects of DNA targeting therapeutic strategies by interfering with DNA repair response cascades. Therefore, the continuously growing evidence supporting hyperthermia's beneficial role in cancer treatment can also encourage its application as a DNA repair mitigation strategy. In this review article, we aim to provide detailed information on how hyperthermia acts on DNA damage and repair pathways and thus potentially contributing to various adjuvant therapeutic protocols relevant to more efficient cancer treatment strategies. 

DNA hasarı yapan kanser tedavilerinin yararını arttırmada hiperterminin etkinliği

İngiltere, Amerika Birleşik Devletleri ve Yunanistan’ dan bilim insanlarının ortaklaşa yaptığı araştırmada hiperterminin kemoterapi ve / veya radyoterapinin yanında tamamlayıcı tedavi olarak uygulandığında tedavinin kanser hücrelerini öldürücü etkisini nasıl arttırdığı anlatılmaktadır.

Kanser hücrelerinin DNA’ sında tıbbi tedavi ile yaratılan öldürücü hasar kanser hücrelerinin koruyucu mekanizmaları tarafından tamir edilmektedir. Hipertermi kanser hücrelerindeki hasarın tamirini engellemede fayda sağlamaktadır. Kendisini tamir etme yeteneğini hipertermi uygulaması ile kaybeden kanser hücreleri tıbbi tedavi ile daha kolay öldürülmektedir.

Ek bilgi için iletişim telefonlarından yardım alabilirsiniz.

 

Semin Cancer Biol. 2016 Jun;37-38:96-105. doi: 10.1016/j.semcancer.2016.03.004. Epub 2016 Mar 26.

Effects of hyperthermia as a mitigation strategy in DNA damage-based cancer therapies.

Mantso T1, Goussetis G2, Franco R3, Botaitis S4, Pappa A5, Panayiotidis M6.


Author information

• 1 School of Life Sciences, Heriot Watt University, Edinburgh, Scotland, UK.

• 2 School of Engineering & Physical Sciences, Heriot Watt University, Edinburgh, Scotland, UK.

• 3 School of Veterinary Medicine & Biomedical Sciences, University of Nebraska-Lincoln, USA.

• 4 Second Department of Surgery, Democritus University of Thrace, Alexandroupolis, Greece.

• 5 Department of Molecular Biology & Genetics, Democritus University of Thrace, Alexandroupolis, Greece.

• 6 School of Life Sciences, Heriot Watt University, Edinburgh, Scotland, UK. Electronic address: M.Panagiotidis@hw.ac.uk.


Abstract

Utilization of thermal therapy (hyperthermia) is defined as the application of exogenous heat induction and represents a concept that is far from new as it goes back to ancient times when heat was used for treating various diseases, including malignancies. Such therapeutic strategy has gained even more popularity (over the last few decades) since various studies have shed light into understanding hyperthermia's underlying molecular mechanism(s) of action. In general, hyperthermia is applied as complementary (adjuvant) means in therapeutic protocols combining chemotherapy and/or irradiation both of which can induce irreversible cellular DNA damage. Furthermore, according to a number of in vitro, in vivo and clinical studies, hyperthermia has been shown to enhance the beneficial effects of DNA targeting therapeutic strategies by interfering with DNA repair response cascades. Therefore, the continuously growing evidence supporting hyperthermia's beneficial role in cancer treatment can also encourage its application as a DNA repair mitigation strategy. In this review article, we aim to provide detailed information on how hyperthermia acts on DNA damage and repair pathways and thus potentially contributing to various adjuvant therapeutic protocols relevant to more efficient cancer treatment strategies.

 

 


 

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