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Lenfomada hiperterminin etkisi

Lenfomada hiperterminin etkisi

Kategori   Hipertermi   Lenfoma   | 11/29/2016

Lenfomada hiperterminin etkisi 

Effect of hyperthermia on AKR lymphoma variants differing in degree of malignancy. 

 

Cancer Invest. 2001;19(8):791-8.

Sharabi Y1, Klorin G, Leibovici J.

 

Author information

• 1Department of Internal Medicine D, The Chaim Sheba Medical Center, Tel Hashomer, Israel. yina@internet-zahav.net

 

Abstract

The effect of hyperthermic treatment on AKR lymphoma cells of varying malignancy was investigated. Tumor cells were pretreated at 37 or 43 degrees C and then injected to mice. The effect on the highly malignant variant, TAU-38, was compared to that on the low-malignancy variant, TAU-39, following both subcutaneous (s.c.) and intravenous (i.v.) inoculation. Hyperthermia showed no effect on the TAU-39 variant following s.c. inoculation on the primary tumors or mice survival, but the TAU-38 variant exhibited a significant delay of tumor appearance following treatment, namely, decreased tumor size and increased life span. Following i.v. inoculation, in both variants, hyperthermia caused a significant decrease in metastatic spread and an increased life span. We conclude that hyperthermia, in addition to exerting a greater effect on the high-malignancy variant, acts at the late phases of metastasis. Hyperthermia might therefore have a place in the management of cancer in its advanced disseminated phase.